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Dr. Alvaro Raúl Lara Rodríguez Departamento de Procesos y Tecnología

Resumen Curricular

  • Ingeniero Bioquímico ENCB-IPN (2001)
  • Doctor en Ciencias IBt-UNAM (2007)
  • Investigador Nacional Nivel II

Distinciones:

·  Premio Carlos Casas Campillo, Sociedad Mexicana de Biotecnología y Bioingeniería (2014)

·  Mención Honorífica en Examen de Doctorado (2007)

·  Premio Hy-Clone-Sociedad Mexicana de Biotecnología y Bioingeniería (2003)

·  Mención Honorífica en Examen de Licenciatura (2001)

- Premio a las mejores Tesis de Licenciatura del IPN (2001)

Área de interés/experiencia en investigación

Ingeniería Bioquímica. Ingeniería Biológica. Biomanufactura.

Publicaciones en Revistas

Últimos 5 años:

- Sigala JC, Suárez BP, Lara AR, Le Borgne S, Bustos P, Santamaría RI, González V, Martinez A. 2017. Genomic and physiological characterization of a laboratory-isolated Acinetobacter schindleri ACE strain that quickly and efficiently catabolizes acetate. Microbiology. In press.

- Jaén KE, Sigala JC, Olivares-Hernández R, Niehaus K, Lara AR. 2017. Heterogeneous oxygen availability affects the titer and topology but not the fidelity of plasmid DNA produced by Escherichia coli. BMC Biotechnology. 17(1): 60.

- Juárez M, Memún M, Sigala JC, Lara AR. 2017. Aerobic expression of Vitreoscilla hemoglobin improves the growth performance of CHO-K1 cells. Biotechnology Journal. 12(3).

- Lara AR, Jaén KE, Sigala JC, Mühlmann M, Regestein L, Büchs J. 2016. Characterization of Endogenous and Reduced Promoters for Oxygen-Limited Processes Using Escherichia coli. ACS Synthetic Biology.  6 (2), pp 344–356.

- Baert J, Delepierre A, Telek S, Toye D, Delamotte A, Lara AR, Gosset G, Jensen P, Delvigne, F. 2016. Microbial population heterogeneity versus bioreactor heterogeneity: evaluation of Redox Sensor Green as an exogenous metabolic biosensor. Eng Life Sci. 16(7): 643-651.

- Pablos TE, Olivares R, Sigala JC, Ramírez OT, Lara AR. 2016. Toward efficient microaerobic processes using engineered Escherichia coli W3110 strains. Eng Life Sci. 16(7): 588-597

- Galindo J, Barrón BL, Lara AR. 2016. Plasmid DNA production in shake flasks is improved by enzyme-controlled glucose release. Annals Microbiol. 66(3): 1337-1342.

- Ramírez EA, Velázquez D, Lara AR. 2016. Enhancing plasmid DNA production in shake flask by enzyme-mediated glucose release and engineered E. coli. Biotechnol Lett. 38(4): 651-657.

- Cortés T, Flores N, Bolívar F, Lara AR, Ramírez OT. 2016. Physiological effects of pH gradients on Escherichia coli during plasmid DNA production. Biotechnol Bioeng. 113(3): 598-611.

- Freudenau I, Lutter P, Baier L, Schleef M, Bednarz H, Lara AR, Niehaus K. 2015. Col E1 plasmid production in Escherichia coli: mathematical simulation andexperimental validation. Frontiers in Bioengineering and Biotechnology. 3:127

·  Delvigne F, Lara AR, Al-Soud W, Sorensen SJ. 2014. Metabolic variability in bioprocessing: implications of microbial phenotypic heterogeneity.Trends Biotechnol. 32(12): 608-616.

·  Beltrán NE, Reyes A, Lara AR. 2014. Cardiac tissue engineering as an alternative to current therapies: economical and technical challenges. Exp Clin Card. 20 (8): 3375-3388.

·  Gálvez R, Pablos TE, Sigala JC, Lara AR. 2014. Co-utilization of glucose and xylose increases plasmid DNA production by engineered Escherichia coli. Rev Mex Ing Quim. 13(2): 387-391.

·  Pablos TE, Sigala JC, Le Borgne S, Lara AR. 2014. Aerobic expression of Vitreoscilla hemoglobin efficiently reduces overflow metabolism in Escherichia coli. Biotechnol J. 9(6): 791-799.

·  Licona-Cassani C, Lara A.R., Cabrera-Valladares N, Hernández-Chávez G, Escalante A, Martínez A, Bolívar F, Gosset G. 2014 Inactivation of pyruvate kinase or the phosphoenolpyruvate:sugar phosphotransferase system increases shikimic and dehydroshikimic acid yields from glucose in Bacillus subtilis engineered strains. J Mol Microbiol Biotechnol. 24: 37-45.

·  Wunderlich M, Taymaz-Nikerel H, Gosset G, Ramírez OT, Lara AR. 2014. Effect of growth rate on plasmid DNA production and metabolic performance of engineered Escherichia coli strains. J Biosci Bioeng. 17(3): 336-342.

·  Jaén KE, Lara AR, Ramírez OT. 2013. Effects of heating rate on pDNA production by E. coli. BiochemEng J. 79: 230-238.

·  Caspeta L, Lara AR, Ramírez OT. 2013. Enhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies. J Biotechnol. 167:47-55.

·  Fuentes LG, Lara AR, Martínez LM, Ramirez OT, Martínez A, Bolívar F, Gosset G. 2013. Modification of glucose import capacity in Escherichia coli: physiologic consequences and application to improve DNA vaccine production. Microb Cell Fact. 12:42.

 

Memorias de Congreso

Capítulos en Libros

Últimos 5 años

- Lara AR, Palomares LA, Ramírez OT. 2017. Scale-down: Simulating large-scale cultures in the laboratory. En: Industrial Biotechnology: Products and Processes. Wiley‐VCH Verlag GmbH & Co. KGaA. pp. 55-79.

·  Mairhofer J, Lara AR. 2014. Advances in strains and vector development for plasmid DNA vaccines production. En: Cancer Vaccines Methods and Protocols. Springer/Humana Press.

 

Libros

Formación de Recursos Humanos

Otra Información de Relevancia Académica

Patentes

·  Lara AR, Borja GM, Gosset G, Ramírez OT. 2011. Cepa de Escherichia coli con mutaciones para la alta producción de ácidos nucleicos recombinantes y su uso en cultivos de alta densidad celular en modo lote. UAM. México. En trámite. Folio: MX/a/2011/013392.

·  Lara AR, Vázquez MC, Gosset G, Bolívar FG, Lopez-Munguia A, Ramirez OT. 2006. Estrategia para generar células insensibles a condiciones heterogéneas en biorreactores industriales a través de mutaciones de vías metabólicas anaerobias. UNAM México. En trámite.