Área de interés/experiencia en investigación

Áreas de interés y de investigación:

• Biomedicina, diseño de fármacos y bioinformática  
• Estudios de estabilidad y estructura de biomoléculas
• Análisis computacional de biomoléculas
• Reconocimiento proteína-ligando y acoplamiento simulado o docking
• Inhibidores de enzimas
• Proteasas sulfhidrílicas
• Espectroscopía y calorimetría de proteínas

Publicaciones en Revistas

Publicaciones relevantes recientes

Antineoplastic effect of compounds C14 and P8 on TNBC and radioresistant TNBC cells by stabilizing the K-Ras4BG13D/PDE6δ complex

Dayan A Carrión-Estrada, Arturo Aguilar-Rojas, Sara Huerta-Yepez, Mayra Montecillo-Aguado, Martiniano Bello, Arturo Rojo-Domínguez, Elena Arechaga-Ocampo, Paola Briseño-Díaz, Marco Antonio Meraz-Ríos, María del Rocío Thompson-Bonilla, Rosaura Hernández-Rivas, Miguel Vargas. Frontiers in Oncology. (2024) 14, 1341766. https://doi.org/10.3389/fonc.2024.1341766

KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation   

Antonia González-Garrido, Omar López-Ramírez, Abel Cerda-Mireles, Thania Navarrete-Miranda, Aranza Iztanami Flores-Arenas, Arturo Rojo-Domínguez, Leticia Arregui, Pedro Iturralde, Erika Antúnez-Argüelles, Mayra Domínguez-Pérez, Leonor Jacobo-Albavera, Alessandra Carnevale, Teresa Villarreal-Molina. International Journal of Molecular Sciences. (2024) 25 (2), 953. https://doi.org/10.3390/ijms25020953

Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer     Open Access

Paola Briseño-Díaz, Michael Schnoor, Martiniano Bello-Ramirez, Jose Correa-Basurto, Arturo Rojo-Domínguez, Leticia Arregui, Libia Vega, Enrique Núñez-González, Luis Andres Palau-Hernández, Carlos Guadalupe Parra-Torres, Óscar Manuel García Córdova, Ernesto Zepeda-Castilla, Eduardo Torices-Escalante, Leticia Domínguez-Camacho, Beatriz Xoconostle-Cazares, Marco Antonio Meraz-Ríos, Sandra Delfín-Azuara, Dayan Andrea Carrión-Estrada, Nicolas Villegas-Sepúlveda, Rosaura Hernández-Rivas, Maria del Rocio Thompson-Bonilla, Miguel Vargas. (2023) Life Science Alliance. Oct 2023, 6 (12) e202302019 (2023) 41:2, 423-434. https://doi.org/10.26508/lsa.202302019

Hen lysozyme fibrillogenesis, molten globule intermediate and effect of copper salts
Ricardo Cerón, Mariana Peimbert, Arturo Rojo-Domínguez, Hugo Nájera. Journal of Biomolecular Structure & Dynamics. (2023) 41:2, 423-434. https://doi.org/10.1080/07391102.2021.2006090

Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis

Claudia G. Benítez-Cardoza, Luis G. Brieba, Rossana Arroyo, Arturo Rojo-Domínguez, José L. Vique-Sánchez. Archiv der Pharmazie (2022) 355 (6), 2200046. https://doi.org/10.1002/ardp.202200046

Leukocyte Nuclear Morphology Alterations in Dilated Cardiomyopathy Caused by a Lamin AC Truncating Mutation (LMNA/Ser431*) Are Modified by the Presence of a LAP2 Missense Polymorphism (TMPO/Arg690Cys)

Antonia González-Garrido, Sandra Rosas-Madrigal, Arturo Rojo-Domínguez, Jaime Arellanes-Robledo, Enrique López-Mora, Alessandra Carnevale, Leticia Arregui, Rigoberto Rosendo-Gutiérrez, Sandra Romero-Hidalgo and María Teresa Villarreal-Molina. International Journal of Molecular Sciences. (2022) 23(21):13626. https://doi.org/10.3390/ijms232113626

Triosephosphate isomerase as a therapeutic target against trichomoniasis
Claudia Guadalupe Benítez-Cardoza, Luis G. Brieba, Rossana Arroyo, Arturo Rojo-Domínguez, José L. Vique-Sánchez. Molecular and biochemical parasitology. (2021) 246:111413. https://doi.org/10.1016/j.molbiopara.2021.111413

On the conformational search of a βCD dendritic derivative: NMR and theoretical calculations working together reveal a donut-like amphiphilic structure
Luis José López-Méndez, Yareli Rojas-Aguirre, Hugo Vázquez-Lima, Julia Cassani, Raúl G. Enríquez, Arturo Rojo-Domínguez, Patricia Guadarrama. Journal of Molecular Structure. (2020) 1204:127535
https://doi.org/10.1016/j.molstruc.2019.127535

Enthalpically-driven ligand recognition and cavity solvation of bovine odorant binding protein
Homero Gómez-Velasco, Arturo Rojo-Domínguez, Enrique García-Hernández. Biophys Chem. (2020) 257:106315. https://doi.org/10.1016/j.bpc.2019.106315

Laccases: structure, function, and potential application in water bioremediation
Leticia Arregui, Marcela Ayala, Ximena Gómez-Gil, Guadalupe Gutiérrez-Soto, Carlos Eduardo Hernández-Luna, Mayra Herrera de Los Santos, Laura Levin, Arturo Rojo-Domínguez, Daniel Romero-Martínez, Mario C N Saparrat, Mauricio A Trujillo-Roldán, Norma A Valdez-Cruz. Microb Cell Fact. (2019) 18(1):200. https://doi.org/10.1186/s12934-019-1248-0

Molecular dynamics on laccase from Trametes versicolor to examine thermal stability induced by salt bridges
Leonardo David Herrera-Zúñiga, Cesar Millán-Pacheco, Gustavo Viniegra-González, Elba Villegas. Leticia Arregui, Arturo Rojo-Domínguez. Chemical Physics. (2019) 517:253-264. https://doi.org/10.1016/j.chemphys.2018.10.019

What comparisons of natural and chimeric contacts reveal about inhibition of human cathepsins K, L and S by their prosegments
Juan Carlos Martínez-Hernández, Iris N. Serratos, César Millán-Pacheco, Arturo Rojo-Domínguez, Jaqueline Padilla-Zúñiga. J. Mex. Chem. Soc. (2019) 63(1):13-24. https://doi.org/10.29356/jmcs.v62i4.684

The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo
Cruz-Nova P, Schnoor M, Correa-Basurto J, Bello M, Briseño-Díaz P, Rojo-Domínguez A, Ortiz-Mendoza CM, Guerrero-Aguirre J, García-Vázquez FJ, Hernández-Rivas R, Thompson-Bonilla MDR, Vargas M. BMC Cancer. (2018) 18(1):1056. https://doi.org/10.1186/s12885-018-4968-3

Prevalence and ancestral origin of the c.1987delC GAA gene mutation causing Pompe disease in Central Mexico
Adriana Grijalva-Pérez, Carmen Esmer, Sandra Romero-Hidalgo, Arturo Rojo-Domínguez, Sandra Rosas-Madrigal, Rafael Velázquez-Cruz, Teresa Villarreal-Molina, Victor Acuña-Alonzo, Antonio Bravo-Oro, Alessandra Carnevale. Meta Gene. (2018) 15: 60-64. https://doi.org/10.1016/j.mgene.2017.11.005

KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer
Casique-Aguirre D, Briseño-Díaz P, García-Gutiérrez P, la Rosa CHG, Quintero-Barceinas RS, Rojo-Domínguez A, Vergara I, Medina LA, Correa-Basurto J, Bello M, Hernández-Rivas R, Thompson-Bonilla M, Vargas M. BMC Cancer. (2018) Dec 29; 18(1):1299. https://doi.org/10.1186/s12885-018-5142-7

Compound heterozygous KCNQ1 mutations (A300T/P535T) in a child with sudden unexplained death: Insights into possible molecular mechanisms based on protein modeling
Antúnez-Argüelles E, Rojo-Domínguez A, Arregui-Mena AL, Jacobo-Albavera L, Márquez MF, Iturralde-Torres P, Villarreal-Molina MT. Gene. (2017) Sep 5; 627:40-48. https://doi.org/10.1016/j.gene.2017.06.011

A new nucleocytoplasmic RhoGAP protein contributes to control the pathogenicity of Entamoeba histolytica by regulating EhRacC and EhRacD activity
Hernandez-Flores A, Almaraz-Barrera MJ, Lozano-Amado D, Correa-Basurto J, Rojo-Domínguez A, Luna-Rivera E, Schnoor M, Guillen N, Hernandez-Rivas R, Vargas M. Cellular Microbiology. (2016). Nov; 18 (11): 1653-1672. https://doi.org/10.1111/cmi.12603

Multinucleation and Polykaryon Formation is Promoted by the EhPC4 Transcription Factor in Entamoeba histolytica
Hernández de la Cruz O, Marchat LA, Guillén N, Weber C, López Rosas I, Díaz-Chávez J, Herrera L, Rojo-Domínguez A, Orozco E, López-Camarillo C. Scientific Reports. Nature. (2016) Jan 21; 6: 19611. https://doi.org/10.1038/srep19611

Memorias de Congreso

Multi-agent systems applied in the modeling and simulation of biological problems: A case study in protein folding
Pedro Pablo González Pérez, Hiram I Beltrán, Arturo Rojo-Domínguez, Máximo Eduardo, Sánchez Gutiérrez. Revista World Academy of Science, Engineering and Technology. Volumen 58 Páginas 128. Fecha de publicación 2009/10/26. doi.org/10.5281/zenodo.1060185
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Exploring dimensionality, systematic mutations and number of contacts in simple HP ab-initio protein folding using a blackboard-based agent platform
Hiram I Beltrán, Arturo Rojo-Domínguez, Máximo Eduardo Sánchez Gutiérrez, Pedro Pablo, González Pérez. Revista Int J Phys Math Sci.  Volumen 3. Páginas 256-265. Fecha de publicación 2009/4/21. doi.org/10.5281/zenodo.1074373
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